Journal article
Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice
M Klug, RA Hill, KHC Choy, M Kyrios, AJ Hannan, M van den Buuse
Neurobiology of Disease | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2012
Abstract
Psychiatric illnesses, such as schizophrenia, are most likely caused by an interaction between genetic predisposition and environmental factors, including stress during development. The neurotrophin, brain-derived neurotrophic factor (BDNF) has been implicated in this illness as BDNF levels are decreased in the brain of patients with schizophrenia. The aim of the present study was to assess the combined effect of reduced BDNF levels and postnatal stress, simulated by chronic young-adult treatment with the stress hormone, corticosterone. From 6. weeks of age, female and male BDNF heterozygous mice and their wild-type controls were chronically treated with corticosterone in their drinking wate..
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Awarded by Swinburne University of Technology
Funding Acknowledgements
The authors are grateful to Sally Martin and Angela Hurley for assistance with mouse breeding and genotyping. MK was a recipient of a Swinburne University of Technology postgraduate scholarship. This project was furthermore supported by a senior research fellowship (MvdB), a postdoctoral training fellowship (RH), and a project grant (566879) from the National Health and Medical Research Council of Australia. In addition, operational infrastructure support was received from the State Government of Victoria. None of the funding sources had any influence in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication.